Prognostic role of adding a genetic risk score to the new European SCORE2 in a cardiovascular events prediction, in a moderate-risk region

Abstract Introduction The new SCORE2 provides risk estimates for the combined outcome of fatal and non-fatal cardiovascular disease (CVD) events, in contrast with SCORE's use CVD mortality only. Genetic predisposition to is not considered prevention treatment. Purpose Evaluate impact adding a Risk Score (GRS) European MACE prediction estimate additional value stratification an asymptomatic Portuguese population. Methods A prospective study was performed population-based cohort 1,100 individuals without known diabetes (mean age 53.3±6.9 years). For all included participants, calculated three categories were considered: low-, moderate- high-risk. 33-SNP GRS constructed two groups analyzed: lower higher than median. Kaplan-Meier survival curves created Cox regression model scores assess risk. C-statistic methodology compared between solely plus GRS. Results After analysis occurrence, high SCORE 2 showed worst when (p<0.0001). presented HR 8.528 (p=0.001) high-risk 4.520 (p<0.0001) demonstrated that predictive 0.678, increasing 0.792 (p=0.0005). Conclusions In this work, combining multiple genetic loci gathered into GRS, improved identification patients prognosis. This tool may be great utility primary prevention. Larger multicenter cohorts longer follow-up should reproduce validate these findings. Funding Acknowledgement Type funding sources: Public hospital(s). Main source(s): SESARAM EPERAM